PGS is a relatively new technique used to test embryos for chromosomal abnormalities. It involves testing the chromosomes of each embryo before it is transferred into the uterus. This process can improve the success rate of in vitro fertilization Best IVF Center in Pakistan and reduce the risk of miscarriage In IVF, eggs are removed from the ovaries, fertilised in a laboratory and then implanted back into the uterus. The fertilised egg is tested for chromosomal abnormalities before it is transferred. The goal of PGS is to identify abnormal embryos that are unlikely to survive or thrive in the womb. Embryos with aneuploidy (chromosome abnormalities) have a higher risk of miscarriage and birth defects than normal embryos. PGS has been available for more than 10 years, but its use has increased dramatically in recent years as more clinics adopt this technology and as couples seek ways to improve their chances of having a successful pregnancy and healthy baby.
IVF offered as an infertility treatment for couples with age 35 or above age couple. It is used to treat many causes of infertility: Older women damage or blockage of the pelvic arteries (which may result from pelvic inflammatory disease or past surgery)
The Society for Reproductive Technologies (SART) says the birth rate via in vitro fertilization for women under 35 approx 55.7%. The birth rate in the first embryo transfer approx 41.3%. Birth rate in second embryo transfer is around approx 47.1%.
As per World Bank census of , the fertility rate in Pakistan is 3.45 per woman. The current fertility rate of Pakistan is 3.300 per woman containing approximate 1.87% decline from 2022 (United Nations – World Population Prospects). The fertility rate in Pakistan is gradually decreasing. The world average successful pregnancy rate through IVF is over 40%. Chances of successful pregnancy increase by 44% to 53% in IVF. PGS analyses cells obtain through biopsy from embryos to screen them for potential genetic abnormalities in the absence of known potential hereditary disorders. Whereas in PGD the same process is applied to detect certain hereditary disorders that are likely to be passed on from the parent to the offspring.
PGS can detect aneuploidies (abnormal numbers of chromosomes), such as Down syndrome (trisomy 21), Edwards syndrome (trisomy 18), Patau syndrome (trisomy 13), and other chromosomal abnormalities.
PGS and PGD are related but different procedures. PGS primarily screens for chromosomal abnormalities, while PGD focuses on detecting specific genetic conditions or mutations carried by the parents.
PGS improves the chances of selecting chromosomally normal embryos, but it doesn’t guarantee a successful pregnancy. Other factors can influence the success of IVF, including embryo quality and the mother’s reproductive health.
