Australian Concept Infertility Medical Center Islamabad

Genetics-> PGT

Pre-implantation Genetic Testing

What is a PGT?

Many parents dream of achieving a balanced family, and this desire often extends to those who wish for sons after having daughters and vice versa. Pre-Implantation Genetic Test (PGT) offers a solution for couples seeking to fulfill their wishes for a balanced family. PGT allows for the identification of embryos as either XX (girl) or XY (boy) before they are implanted into the mother's womb. This technique ensures the selection of desired embryos for implantation, thus enhancing the chances of having a child of the preferred gender. Notably, PGD is also employed to identify inheritable genetic diseases, making it a versatile and valuable tool for family planning and ensuring the health of future generations. With an accuracy rate of up to 99.9%, PGD offers hope and confidence to couples as they embark on their journey towards a balanced and healthy family.

Preimplantation genetic testing

Working & Procedure of PGT

PGT is a technique that enables couples with a particular inherited condition in their family to avoid passing it on to their children. The process helps potential parents prevent the birth of a child with a serious genetic condition. The procedure for PGD is similar to that of in vitro fertilizations (IVF), with an extra step to check whether embryos are affected by a serious genetic condition

Pre-implantation genetic diagnosis
Process or Stages in ICSI

Who Benefits from PGT

PGT (Preimplantation Genetic Diagnosis) stands as a beacon of hope for couples grappling with irreversible infertility challenges. You may be familiar with the intertwining of PGD with infertility treatments, and this is because PGD serves as a potent tool in addressing various underlying infertility causes, especially in cases of genetic abnormalities. Conventional IVF procedures often rely on a certain number of healthy sperm and optimal functionality for successful fertilization. However, PGD sidesteps these requirements by meticulously assessing the genetic makeup of embryos in a laboratory setting. This comprehensive genetic analysis allows for the selection of the healthiest embryos, significantly enhancing the likelihood of a successful pregnancy and the birth of a healthy child.



Who needs IVF

IVF offered as an infertility treatment for couples with age 35 or above age couple. It is used to treat many causes of infertility: Older women damage or blockage of the pelvic arteries (which may result from pelvic inflammatory disease or past surgery)

How Successful is IVF?

The Society for Reproductive Technologies (SART) says the birth rate via in vitro fertilization for women under 35 approx 55.7%. The birth rate in the first embryo transfer approx 41.3%. Birth rate in second embryo transfer is around approx 47.1%.

PGT Success Factors

In the realm of assisted reproductive technologies, the success of Preimplantation Genetic Testing (PGT) hinges on several critical factors. PGT, often used in conjunction with In Vitro Fertilization (IVF), offers hope to couples dealing with genetic disorders, recurrent pregnancy loss, or advanced maternal age. The effectiveness of PGT is significantly influenced by the accuracy of genetic testing, the quality of embryo biopsy, and the selection of euploid embryos for transfer. These success factors not only ensure a higher likelihood of a healthy pregnancy but also play a pivotal role in reducing the risk of genetic abnormalities in the offspring. The precision of PGT testing methods, the expertise of embryologists performing the biopsy, and the ability to identify chromosomally normal embryos are paramount in achieving the desired outcome. Additionally, the timing of embryo transfer and the receptivity of the uterine lining are crucial determinants of PGT success. Couples embarking on the PGT journey can find assurance in the meticulous attention to these factors, ultimately increasing their chances of a successful and healthy pregnancy.

Success Processes

Age and Success Rates

Age is an essential factor that impacts the success of an IVF treatment. With the increase in age, the probability of IVF success decreases. The success rate of IVF resulting in live birth is 31% in women under the age of 35, 24% in women 35-37, and only 16% in women who are 38-40.

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Lifestyle and Health

A balanced lifestyle and healthy diet provide the human body with adequate vitamins, nutrients, and minerals that are necessary for the production of healthy sperm and eggs, which ultimately increases the chances of IVF success.

Previous Treatment

Previous Treatments

Previous fertility treatment can impact your IVF success rate. For instance, if you were unsuccessful in achieving pregnancy in the first cycle of IVF, your chances of pregnancy may increase in subsequent embryo transfer.

Balancing Risks and Rewards

IVF is a safe procedure, but there are some potential IVF risks and complications, such as; IVF risks and complications are negligible, and they fade with time


Frequently Asked Questions

What does PGT look for?

Parental Genetic Testing (PGT) looks for genetic abnormalities or mutations in embryos before implantation during in vitro fertilization (IVF).

What types of PGT are there?

There are three main types of PGT:
a. PGT-A (formerly known as PGS): Screens for numerical chromosomal abnormalities (e.g., aneuploidy).
b. PGT-M (formerly known as PGD): Identifies specific genetic mutations or disorders within embryos for families at risk of passing on a known genetic condition.
c. PGT-SR: Screens for structural rearrangements in chromosomes, such as translocations or inversions.

Is PGT safe for embryos?

PGT involves a biopsy that removes a small number of cells from the embryo. While it’s generally considered safe, there is a small risk of damage to the embryo during the biopsy process.

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